Mechanical load-induced bone remodeling requires FSTL3 expression
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چکیده
منابع مشابه
Microdamage Repair and Remodeling Requires Mechanical Loading
Bone remodeling is necessary to avoid microdamage accumulation, which could lead to whole-bone failure. Previous studies have shown that this bone-repair mechanism is triggered by osteocyte apoptosis. Through the use of a rodent hindlimb suspension model and tibial four-point bending model, the effects of disuse on microdamage remodeling was examined. At day 0, male rats were assigned to one of...
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Introduction: Timely healing of patients with fractures or bone defects of the hand is of utmost importance, both to reduce the economic burden of lost work-days, as well as to maximize function of the post-injured hand. Thus, adjuvant therapies that expedite healing are much needed. Exercise is known to promote remodeling in bones that are directly biomechanically stimulated, yet little is kno...
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© 2012 Kwon et al., licensee InTech. This is an open access chapter distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Osteocyte Apoptosis-Induced Bone Resorption in Mechanical Remodeling Simulation – Compu...
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Chronic increases in arterial blood flow elicit an adaptive response of the arterial wall, leading to vessel enlargement and reduction in wall shear stress to physiological baseline value. Release of nitric oxide from endothelial cells exposed to excessive shear is a fundamental step in the remodeling process, and potentially triggers a cascade of events, including growth factor induction and m...
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Transpulmonary pressure and the mechanical stresses of breathing modulate many essential cell functions in the lung via mechanotransduction. We review how mechanical factors could influence the pathogenesis of emphysema. Although the progression of emphysema has been linked to mechanical rupture, little is known about how these stresses alter lung remodeling. We present possible new directions ...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2013
ISSN: 1063-4584
DOI: 10.1016/j.joca.2013.02.126