Mechanical Properties and Morphological Alterations in Fiber-Based Scaffolds Affecting Tissue Engineering Outcomes

Electrospinning is a versatile tool used to produce highly customizable nonwoven nanofiber mats of various fiber diameters, pore sizes, and alignment. It possible create electrospun from synthetic polymers, biobased combinations thereof. The post-processing the end products can occur in many ways, such as cross-linking, enzyme linking, thermal curing, achieve enhanced chemical physical properties. Such multi-factor tunability very promising applications tissue engineering, 3D organs/organoids, cell differentiation. While established methods involve use soluble small molecules, growth factors, stereolithography, micro-patterning, electrospinning involves an inexpensive, labor un-intensive, scalable approach using environmental cues, promote guide proliferation, migration, By influencing morphology, mechanosensing, intracellular communication, nanofibers affect fate cells multitude ways. Ultimately, may have potential precisely form whole organs for regenerative medicine, cellular agriculture, well vitro microenvironments. In this review, focus will be on mechanical characteristics porosity, diameter, crystallinity, strength, alignment, topography scaffolds, impact