Mechanical Stability of Single DNA Molecules
نویسندگان
چکیده
منابع مشابه
Mechanical stability of single DNA molecules.
Using a modified atomic force microscope (AFM), individual double-stranded (ds) DNA molecules attached to an AFM tip and a gold surface were overstretched, and the mechanical stability of the DNA double helix was investigated. In lambda-phage DNA the previously reported B-S transition at 65 piconewtons (pN) is followed by a second conformational transition, during which the DNA double helix mel...
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Piezoresistivity is a fundamental property of materials that has found many device applications. Here we report piezoresistivity in double helical DNA molecules. By studying the dependence of molecular conductance and piezoresistivity of single DNA molecules with different sequences and lengths, and performing molecular orbital calculations, we show that the piezoresistivity of DNA is caused by...
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We briefly present the results of recent experiments of transverse scanning tunneling spectroscopy of homogeneous poly(dG)-poly(dC) DNA molecules and discuss them in the light of theoretical investigation. A semiempirical theoretical model is adopted to describe the transverse tunneling current across a DNA molecule placed between a metallic gold substrate and a metallic STM tip. We show that t...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2000
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(00)76747-6