Mechanism and Regulation of Urea Permeation in a Mammalian Urea Channel
نویسندگان
چکیده
منابع مشابه
Structure and permeation mechanism of a mammalian urea transporter.
As an adaptation to infrequent access to water, terrestrial mammals produce urine that is hyperosmotic to plasma. To prevent osmotic diuresis by the large quantity of urea generated by protein catabolism, the kidney epithelia contain facilitative urea transporters (UTs) that allow rapid equilibration between the urinary space and the hyperosmotic interstitium. Here we report the first X-ray cry...
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1. Urea is present in the cells of the proximal convoluted tubule in a concentration higher than that of the blood or than that of the cells of any of the other kidney tubules. 2. Such a condition can only be reconciled to an assumption of an active secretion (excretion) on the part of these cells. 3. Urea also passes through the glomerular filter with the other crystalloids of the blood plasma...
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The Biqian-10 block, located in Henan Oilfield of Sinopic, contains many thin and interbedded reservoirs, which have been operated by cyclic steam stimulation for 20 years or more. Therefore, it is a challenge to implement the conventional steam flooding. In order to improve the recovery of steam flooding, urea was used to assist steam flooding. Urea can decompose into CO2 and NH3, which are be...
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Leuthardt [1938a] and Bach [1939] have expressed the opinion that in addition to the ornithine cycle there are other mechanisms of urea synthesis in the mammalian liver. Leuthardt [1938a] found that liver of starved guinea-pigs forms urea more rapidly from glutamine than from NH4Cl. He concluded that NH3 cannot be an intermediate in the urea formation from glutamine and that there is a more or ...
متن کاملHigh urea and creatinine concentrations and urea transporter B in mammalian urinary tract tissues.
Although the mammalian urinary tract is generally held to be solely a transit and storage vehicle for urine made by the kidney, in vivo data suggest reabsorption of urea and other urine constituents across urinary tract epithelia. To determine whether urinary tract tissue concentrations are increased as a result of such reabsorption, we measured urea nitrogen and creatinine concentrations and d...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2012
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2011.11.1181