Mechanism of acute tryptophan depletion: is it only serotonin?
نویسندگان
چکیده
منابع مشابه
Serotonin and cognitive flexibility: neuroimaging studies into the effect of acute tryptophan depletion in healthy volunteers.
Cognitive flexibility is the ability to adjust behavior to changes in the environment or task conditions. Previous research suggested that serotonin (5-HT) is involved in cognitive flexibility. Disturbed 5-HT functioning in animals, psychiatric patients and healthy volunteers leads to more rigid behavior. A well recognized method to manipulate levels of brain 5-HT is acute tryptophan depletion ...
متن کاملChallenging the Serotonin System: A Mechanistic Approach to the Method of Acute Tryptophan Depletion in Rodents
Objective: The method of acute tryptophan depletion (ATD) currently represents the most extensively applied challenge test to investigate the implication of the serotonin (5-HT) system in cognitive functions and psychiatric disorders. ATD consists of manipulating the availability of the essential amino acid tryptophan (TRP), the dietary 5-HT precursor, through administration of a TRP-free diet,...
متن کاملPeripheral Serotonin 1B Receptor Transcription Predicts the Effect of Acute Tryptophan Depletion on Risky Decision-Making
Background The effects of acute tryptophan depletion on human decision-making suggest that serotonin modulates the processing of rewards and punishments. However, few studies have assessed which of the many types of serotonin receptors are responsible. Methods Using a within-subject, double-blind, sham-controlled design in 26 subjects, we examined whether individual differences in serotonin s...
متن کاملChapter 4 Tryptophan depletion and serotonin release - a critical reappraisal
tryptophan depletion is often assumed to lead to a decrease in neuronal serotonin release in the brain. here we review the literature and show that only in animal studies in which either serotonin synthesis rate is already decreased or serotonin utilization is increased an effect of tryptophan depletion on serotonin release has been demonstrated. in the absence of convincing evidence for reduce...
متن کاملResponse inhibition and serotonin in autism: a functional MRI study using acute tryptophan depletion
It has been suggested that the restricted, stereotyped and repetitive behaviours typically found in autism are underpinned by deficits of inhibitory control. The biological basis of this is unknown but may include differences in the modulatory role of neurotransmitters, such as serotonin, which are implicated in the condition. However, this has never been tested directly. We therefore assessed ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2011
ISSN: 1359-4184,1476-5578
DOI: 10.1038/mp.2011.9