Mechanism of inactivation of phenylalanine hydroxylase by p-chlorophenylalanine in hepatome cells in culture. Two possible models.
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چکیده
منابع مشابه
Mechanism of Inactivation of Phenylalanine Hydroxylase by p-Chlorophenylalanine in Hepatoma Cells in Culture
The mechanism by which p-chlorophenylalanine specifically reduces phenylalanine hydroxylase activity in rat liver in uiuo and in Reuber H4 hepatoma cells in culture has been investigated. Chromatography on hydroxylapatite of liver extract from rats injected with p-chlorophenylalanine showed that the compound differentially affected the three normal phenylalanine hydroxylase isoenzymes (I, II, a...
متن کاملp-Chlorophenylalanine Effect on Phenylalanine Hydroxylase in Hepatoma Cells in Culture*
We have investigated the p-chlorophenylalanine-dependent loss of phenylalanine hydroxylase activity in cultured hepatoma cells. The similarity of the effect of p-chlorophenylalanine on phenylalanine hydroxylase in the hepatoma cells and that reported from studies in uiuo indicates that the loss of phenylalanine hydroxylase activity is due to a direct interaction of the amino acid analog-ue with...
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The enzymic hydroxylation of phenylalanine by phenylalanine hydroxylase (E.C. 1.14.16.1.) in vitro is dependent on the presence of hydrogen peroxide removing processes. The loss of phenylalanine hydroxylase activity can be prevented to the same extent by catalase as well as the presence of optimized amounts of both peroxidase and superoxide dismutase. Peroxidase alone exhibited only two third o...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1976
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)33397-5