Mechanisms of Immune Evasion and Immune Modulation by Lymphoma Cells
نویسندگان
چکیده
منابع مشابه
Mechanisms of Immune Evasion and Immune Modulation by Lymphoma Cells
Purpose Targeting cancer cells by modulating the immune system has become an important new therapeutic option in many different malignancies. Inhibition of CTLA4/B7 and PD1/PDL1 signaling is now also being investigated and already successfully applied to various hematologic malignancies. Methods A literature review of PubMed and results of our own studies were compiled in order to give a comp...
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While the cellular origin of lymphoma is often characterized by chromosomal translocations and other genetic aberrations, its growth and development into a malignant neoplasm is highly dependent upon its ability to escape natural host defenses. Neoplastic cells interact with a variety of non-malignant cells in the tumor milieu to create an immunosuppressive microenvironment. The resulting funct...
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The Filoviridae family of viruses, which includes the genera Ebolavirus (EBOV) and Marburgvirus (MARV), causes severe and often times lethal hemorrhagic fever in humans. Filoviral infections are associated with ineffective innate antiviral responses as a result of virally encoded immune antagonists, which render the host incapable of mounting effective innate or adaptive immune responses. The T...
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In the past decade, basic studies in animal models have begun to elucidate the physiological barriers which impede a successful antitumor immune response. These barriers operate at a number of levels, and involve the tumor, the tumor microenvironment and various components of the innate and adaptive immune systems. In this review, we discuss the multiple mechanisms by which tumors evade an immu...
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Arenaviruses, such as Lassa virus (LASV), can cause fatal human hemorrhagic fever (HF) diseases for which licensed vaccines and effective therapies are currently unavailable [1]. These viruses have been shown to initiate the infection by targeting the antigen presenting cells (APCs), such as dendritic (DC) and macrophage (MP) cells [1]. While MPs and DCs are readily infected with arenaviruses (...
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ژورنال
عنوان ژورنال: Frontiers in Oncology
سال: 2018
ISSN: 2234-943X
DOI: 10.3389/fonc.2018.00054