Mechanisms of Late-Onset Cognitive Decline after Early-Life Stress
نویسندگان
چکیده
منابع مشابه
Mechanisms of late-onset cognitive decline after early-life stress.
Progressive cognitive deficits that emerge with aging are a result of complex interactions of genetic and environmental factors. Whereas much has been learned about the genetic underpinnings of these disorders, the nature of "acquired" contributing factors, and the mechanisms by which they promote progressive learning and memory dysfunction, remain largely unknown. Here, we demonstrate that a p...
متن کاملLate-Onset Cognitive Impairments after Early-Life Stress Are Shaped by Inherited Differences in Stress Reactivity
Early-life stress (ELS) has been associated with lasting cognitive impairments and with an increased risk for affective disorders. A dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis, the body's main stress response system, is critically involved in mediating these long-term consequences of adverse early-life experience. It remains unclear to what extent an inherited predisposition...
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Recent genome wide association studies have identified a number of single nucleotide polymorphisms associated with late onset Alzheimer's disease (LOAD). We examined the associations of 24 LOAD risk loci, individually and collectively as a genetic risk score, with cognitive function. We used data from 1,626 non-demented older Australians of European ancestry who were examined up to four times o...
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BACKGROUND Studies concerning the effect of different types of leisure activities on various cognitive domains are limited. This study tests the hypothesis that mental, physical, and social activities have a domain-specific protection against cognitive decline. METHODS A cohort of a geographically defined population in China was examined in 2003-2005 and followed for an average of 2.4 years. ...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2005
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.2281-05.2005