Mechanisms of rosacea pathogenesis. A phenotypic approach to therapeutic tactics

Rosacea is a widespread disease worldwide, affecting 5.5% of the human population and accompanied by significant deterioration in patient's quality life. Currently, there are two classifications rosacea, first which based on subtype approach (erythematous-telangiectatic, papulo-pustular, phimatous ophthalmological subtypes), or an individual analysis presented phenotype rosacea. New data pathophysiology rosacea have emerged, show that genetic factors environmental components can cause initiation exacerbation due to violation regulation innate adaptive immune system. In addition, trigger directly interact with cutaneous nervous system and, help neurovascular neuroimmune active neuropeptides, lead manifestation foci. The main mechanisms pathogenesis currently: activation system, disorders neuro-immune regulation, predisposition. pathogenetic make it possible continue diagnostic search therapeutic approaches personalization management tactics for each patient, depending prevalence clinical features course disease. It necessary evaluate advantages disadvantages subtypical phenotypic classification choose most optimal one. article presents arguments this issue, also suggests assessing need switch new order improve effectiveness therapy life patients.