Mechanistic insights into boron-catalysed direct amidation reactions
نویسندگان
چکیده
منابع مشابه
Mechanistic insights into boron-catalysed direct amidation reactions
Centre for Sustainable Chemical Process University, Science Site, South Road, Durha durham.ac.uk Department of Chemistry, University Coll WC1H 0AJ, UK Department of Chemistry, Durham Univer DH1 3LE, UK Department of Chemistry, Imperial Colle London, SW7 2AZ, UK † Electronic supplementary information spectra, computational data and ES 1551614–1551624 and 1563948–1563950. CIF or other electronic ...
متن کاملMechanistic insights into nickamine-catalyzed alkyl-alkyl cross-coupling reactions.
Within the last decades the transition metal-catalyzed cross-coupling of non-activated alkyl halides has significantly progressed. Within the context of alkyl-alkyl cross-coupling, first row transition metals spanning from iron, over cobalt, nickel, to copper have been successfully applied to catalyze this difficult reaction. The mechanistic understanding of these reactions is still in its infa...
متن کاملMechanistic Insights into Hsp104 Potentiation.
Potentiated variants of Hsp104, a protein disaggregase from yeast, can dissolve protein aggregates connected to neurodegenerative diseases such as Parkinson disease and amyotrophic lateral sclerosis. However, the mechanisms underlying Hsp104 potentiation remain incompletely defined. Here, we establish that 2-3 subunits of the Hsp104 hexamer must bear an A503V potentiating mutation to elicit enh...
متن کاملPractical copper(I)-catalysed amidation of aldehydes.
The direct synthesis of amides by insertion into the C-H bond of aldehydes is shown to be a practical procedure through application of cheap, readily available catalysts generated in situ from copper(i) halides and pyridine.
متن کاملDirect NHC-catalysed redox amidation using CO2 for traceless masking of amine nucleophiles.
The N-heterocyclic carbene (NHC)-catalysed redox amidation reaction is poorly developed and usually requires catalytic co-additives for electron-rich amine nucleophiles. We report a masking strategy (using CO2) that couples release of the free amine nucleophile to catalytic turnover, and in doing so, enables direct catalytic redox amidation of electron-rich amines.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemical Science
سال: 2018
ISSN: 2041-6520,2041-6539
DOI: 10.1039/c7sc03595k