Megaloblastic Anaemia Due to Phenobarbitone

Megaloblastic anaemia due to sulphasalazine responding to drug withdrawal alone.

A 60 year old man with ulcerative colitis since 1975 and treated with sulphasalazine, presented with severe megaloblastic anaemia caused by folate deficiency. The drug was stopped, and the anaemia recovered promptly. There was no relapse one year later.

Megaloblastic anaemia due to trimethoprim-sulphamethoxazole therapy in uraemia.

Anaemia associated with phenobarbitone.

white cells could have been studied. The white cell counts on the next two occasions were also low, being 3000 and 4350 cu./mm. respectively, the latter in June 1962, but when she was admitted this time in May 1964 the picture was that of acute myeloblastic leukemia. This was a rare presentation of acute myeloblastic leukemia, this diagnosis should be considered as a possibility Whenever one is...

Aminoaciduria and megaloblastic anaemia.

Urinary amino-acid chromatograms from 23 patients with megaloblastic anaemia have been studied before and after therapy. The most consistent abnormality was an increased taurine or increased taurine/glycine ratio. This was not related directly to deficiency of vitamin B(12) or folic acid or to the degree of anaemia.

Megaloblastic Anaemia in Haemochromatosis.

IN 1877 Muller described a marked bronzed discoloration of the skin in some patients considered to have pernicious anaemia. This observation, confirmed later by Immerman (1879) is likely to be the first record of an association between a macrocytic type of anemia and haemochromatosis. Since that time French (1909), Roth (1915), Bork (1928), Cain (1940), Hotz (1944) and Harvier and Mallarme (193...