Meiotic Recombination: The Essence of Heredity
نویسندگان
چکیده
منابع مشابه
Meiotic Recombination: The Essence of Heredity.
The study of homologous recombination has its historical roots in meiosis. In this context, recombination occurs as a programmed event that culminates in the formation of crossovers, which are essential for accurate chromosome segregation and create new combinations of parental alleles. Thus, meiotic recombination underlies both the independent assortment of parental chromosomes and genetic lin...
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I Five years ago, at this Svmposium. E. L. Tatum I , u , L and J. Lederberg first reported some preliminary experiments on genetic recombination in Escherichia coli K-12 (1946). This report will review subsequent developments in this research, with special emphasis on the application of recombination analysis in bacteria to problems of general genetic interest. The standard textbooks of bacteri...
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Meiotic recombination is essential for the production of viable haploid gametes in sexually-reproducing organisms, and creates new allelic combinations, whichmay facilitate evolution by natural selection and genetic drift (Barton & Charlesworth, 1998). Crossovers between homologous chromosomes establish physical connections (chiasmata) which enable proper chromosome segregation. In the absence ...
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Meiotic recombination generates gene conversion and crossover events that are distributed heterogeneously in the genome. Studies in yeast show that initiation of recombination, which occurs by the formation of DNA double-strand breaks, determines the distribution of gene conversion and crossover events that take place in nearby intervals. Recent data in humans and mice also indicate the presenc...
متن کاملTargeted Stimulation of Meiotic Recombination
Meiotic recombination in Saccharomyces cerevisiae is initiated by programmed DNA double-strand breaks (DSBs), a process that requires the Spo11 protein. DSBs usually occur in intergenic regions that display open chromatin accessibility, but other determinants that control their frequencies and non-random chromosomal distribution remain obscure. We report that a Spo11 construct bearing the Gal4 ...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Biology
سال: 2015
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a016618