Melatonin can be, more effective than N-acetylcysteine, protecting acute lung injury induced by intestinal ischemia-reperfusion in rat model
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چکیده
منابع مشابه
Nimesulide may be more efficient than allopurinol in protecting pancreas from acute ischemia/reperfusion injury in an animal model.
OBJECTIVE To determine the influence of allopurinol and nimesulide in the protection of the pancreas from acute ischemia-reperfusion (I/R) injury. MATERIALS AND METHODS A total of 30 rabbits were divided into 3 groups, group A: acute I/R only; group B: allopurinol (30 mg/kg) was administered intravenously 10 minutes before ischemia; group C: nimesulide (50 mg/kg) was given intraperitoneally 2...
متن کاملProtective Effect of Crataegus Hydroalcoholic Extract on Intestinal Ischemia-Reperfusion Injury in a Rat Model
Objective- This study examined the effect of Crataegus hydroalcoholic extract (CHE) on intestinal ischemia-reperfusion (I/R) in rats. Design- Experimental study Animals- 25 adult male Wistar rats Procedures- Rats weighing 200±25 g were randomly divided into five individual groups as follows: sham group without...
متن کاملN-acetylcysteine Prevents Kidney and Lung Disturbances in Renal Ischemia/Reperfusion Injury in Rat
BACKGROUND One of the most common causes of acute kidney injury (AKI) is kidney ischemia/reperfusion injury (IRI). The distant organ injury such as acute lung injury is one of the side effects of AKI or kidney IRI. In this study, we performed bilateral renal IRI in rats and the protective role of N-acetylcysteine (NAC) in kidney and lung was investigated. METHODS Rats (n = 30) were randomly a...
متن کاملEffects of N-acetylcysteine and pentoxifylline on remote lung injury in a rat model of hind-limb ischemia/reperfusion injury
OBJECTIVE To investigate the effects of N-acetylcysteine (NAC) and pentoxifylline in a model of remote organ injury after hind-limb ischemia/reperfusion (I/R) in rats, the lungs being the remote organ system. METHODS Thirty-five male Wistar rats were assigned to one of five conditions (n = 7/group), as follows: sham operation (control group); hind-limb ischemia, induced by clamping the left f...
متن کاملEffects of n-acetylcysteine in a rat model of ischemia and reperfusion injury.
OBJECTIVE Splanchnic artery occlusion shock (SAO) causes an enhanced formation of reactive oxygen species (ROS), which contribute to the pathophysiology of shock. Here we have investigated the effects of n-acetylcysteine (NAC), a free radical scavenger, in rats subjected to SAO shock. METHODS AND RESULTS Treatment of rats with NAC (applied at 20 mg/kg, 5 min prior to reperfusion, followed by ...
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ژورنال
عنوان ژورنال: Clinics
سال: 2021
ISSN: 1807-5932,1980-5322
DOI: 10.6061/clinics/2021/e2513