Memory T cells count their ancestors
نویسندگان
چکیده
منابع مشابه
Memory T cells and their costimulators in human allograft injury.
Both CD4(+) and CD8(+) human memory but not naive T cells respond to allogeneic human dermal microvascular endothelial cells (HDMEC) in vitro by secreting cytokines and by proliferating. Several recently identified costimulators, namely, 4-1BB ligand, ICOS ligand, and OX40 ligand, are up-regulated on cultured HDMEC in response to TNF or coculture with allogeneic T cells. Blockade of these costi...
متن کاملT cells count and then decide
JCB • VOLUME 180 • NUMBER 4 • 2008 650 T cells count and then decide T cells tabulate the density of antigens in their surroundings before deciding whether to activate, say Sarah Henrickson, Ulrich von Andrian (Harvard Medical School, Boston, MA), and colleagues. In a prior study, von Andrian says, his group had noticed T cells within lymph nodes fl it “like bumblebees” from one antigen-present...
متن کاملFrequency of Efficient Circulating Follicular Helper T Cells Correlates with Dyslipidemia and WBC Count in Atherosclerosis
Background: The significance of cTfh cells and their subsets in atherosclerosis is not well understood. We measured the frequency of cTfh subsets in patients with different degrees of stenosis using flow-cytometry. Methods: Participants included high (≥50%; n = 12) and low (<50%; n = 12) stenosis groups, as well as healthy controls (n = 6). Results: The frequency of CCR7loPD-1hiefficient-cTfh w...
متن کاملMemory T Follicular Helper CD4 T Cells
T follicular helper (Tfh) cells are the subset of CD4 T helper cells that are required for generation and maintenance of germinal center reactions and the generation of long-lived humoral immunity. This specialized T helper subset provides help to cognate B cells via their expression of CD40 ligand, IL-21, IL-4, and other molecules. Tfh cells are characterized by their expression of the chemoki...
متن کاملSnapShot: Resident Memory T Cells
Resident memory T cells (TRM) comprise a subset of nonrecirculating memory T cells that remain positioned at common portals of reinfection. These include barrier tissues such as the mucosae and skin. TRM orchestrate the initial response to pathogens re-encountered at these locales, thereby accelerating protective immune responses.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Immunology
سال: 2005
ISSN: 1474-1733,1474-1741
DOI: 10.1038/nri1692