Mesenchymal stem cell encapsulation in alginate micro-particles for intra-articular injection in osteoarthritis
نویسندگان
چکیده
منابع مشابه
Intra-articular injection of autologous mesenchymal stem cells in six patients with knee osteoarthritis.
BACKGROUND Osteoarthritis (OA) is a progressive disorder of the joints caused by gradual loss of articular cartilage, which naturally possesses a limited regenerative capacity. In the present study, the potential of intra-articular injection of mesenchymal stem cells (MSCs) has been evaluated in six osteoarthritic patients. METHODS Six female volunteers, average age of 54.56 years, with radio...
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Efficacy Intra-articular corticosteroid injection is quick and simple to carry out and in RCTs it has a large effect size (ES) of 1.27 at 7 days postinjection for pain relief against placebo for knee OA [101]. It produces relatively rapid relief of severe pain within a few hours or days. Although this benefit is relatively short lasting, in RCTs (1–4 weeks), individual patients may derive benef...
متن کاملMesenchymal Stem Cell Purification from the Articular Cartilage Cell Culture
Objective Articular cartilage as an avascular skeletal tissue possesses limited capacity to heal. On the other hand, it is believed that the regeneration capacity of each tissue is largely related to its stem cell contents. Little is known about the presence of mesenchymal stem cells in articular cartilage tissue. This subject is investigated in the present study. Materials and Methods Artic...
متن کاملEffects of intra-articular injection of mesenchymal stem cells associated with platelet-rich plasma in a rabbit model of osteoarthritis.
The current study aims to evaluate the macroscopic and histological effects of autologous mesenchymal stem cells (MSC) and platelet-rich plasma on knee articular cartilage regeneration in an experimental model of osteoarthritis. Twenty-four rabbits were randomly divided into four groups: control group, platelet-rich plasma group, autologous MSC undifferentiated group, and autologous MSC differe...
متن کاملIntra-articular injection of synovial mesenchymal stem cells improves cartilage repair in a mouse injury model.
Controversy remains whether articular cartilage has an endogenous stem/progenitor cell population, since its poor healing capacity after injury can lead to diseases such as osteoarthritis. In the joint environment there are mesenchymal stem/progenitor cells (MSCs) in the synovial membrane and synovial fluid that can differentiate into cartilage, but it is still under debate if these cells contr...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2019
ISSN: 1063-4584
DOI: 10.1016/j.joca.2019.02.442