Mesenteric Circulation in Hemorrhagic Shock

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Mesenteric circulation in hemorrhagic shock.

THE relationship of portal venous to mesenteric arterial pressure during normovolemic hemorrhagic shock suggests that significant volumes of blood may be pooled out of active circulation in the mesenteric vasculature, thus contributing to the development of irreversibility. This contention has received some support from reports by Delorme et al.,who detected elevation of intestinal red cell vol...

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Post-hemorrhagic shock mesenteric lymph is an important contributor to cardiac dysfunction following hemorrhagic shock.

PURPOSE To evaluate whether post-hemorrhagic shock mesenteric lymph (PSML) is involved in cardiac dysfunction induced by hemorrhagic shock. METHODS The hemorrhagic shock model (40±2 mmHg, 3h) was established in rats of the shock and shock+drainage groups; and PSML drainage was performed from hypotension 1-3h in the shock+drainage rats. Then, the isolated hearts were obtained from the rats for...

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Induced hypothermia during resuscitation from hemorrhagic shock attenuates microvascular inflammation in the rat mesenteric microcirculation.

Microvascular inflammation occurs during resuscitation following hemorrhagic shock, causing multiple organ dysfunction and mortality. Preclinical evidence suggests that hypothermia may have some benefit in selected patients by decreasing this inflammation, but this effect has not been extensively studied. Intravital microscopy was used to visualize mesenteric venules of anesthetized rats in rea...

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Ubiquinol decreases hemorrhagic shock/resuscitation‐induced microvascular inflammation in rat mesenteric microcirculation

Hemorrhagic shock (HS) is a leading cause of death in traumatic injury. Ischemia and hypoxia in HS and fluid resuscitation (FR) creates a condition that facilitates excessive generation of reactive oxygen species (ROS). This is a major factor causing increased leukocyte-endothelial cell adhesive interactions and inflammation in the microcirculation resulting in reperfusion tissue injury. The ai...

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ژورنال

عنوان ژورنال: Circulation Research

سال: 1961

ISSN: 0009-7330,1524-4571

DOI: 10.1161/01.res.9.3.561