Metabolic programming of obesity in utero: is there sufficient evidence to explain increased obesity rates?

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Maternal Obesity, Metabolic Health, and Prenatal Programming of Offspring Obesity

Children born to overweight and obese women, as compared to those of normal weight women, have greater risk for becoming obese themselves and suffering comorbid metabolic health problems. Evidence is accumulating that this increased susceptibility is at least partially attributed to a prenatal programming effect, whereby obesogenic factors in the intrauterine environment alter fetal development...

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Epigenetic programming of obesity and diabetes by in utero exposure to gestational diabetes mellitus.

It is now well accepted that offspring exposed to maternal undernutrition, obesity, or gestational diabetes mellitus have an increased risk for chronic diseases later in life, supporting the theory of the early origins of chronic diseases. However, the molecular mechanisms through which the exposure to an altered in utero environment translates into the development of chronic diseases are not y...

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ژورنال

عنوان ژورنال: Journal of Developmental Origins of Health and Disease

سال: 2011

ISSN: 2040-1744,2040-1752

DOI: 10.1017/s2040174411000705