Metabolic Reprogramming in Immune Response and Tissue Inflammation

HIF1α and metabolic reprogramming in inflammation.

HIF1α is a common component of pathways involved in the control of cellular metabolism and has a role in regulating immune cell effector functions. Additionally, HIF1α is critical for the maturation of dendritic cells and for the activation of T cells. HIF1α is induced in LPS-activated macrophages, where it is critically involved in glycolysis and the induction of proinflammatory genes, notably...

Metabolic Reprogramming and Inflammation Act in Concert to

HIF 1 α and metabolic reprogramming in inflammation

Introduction ATP production is required to support physiological function in all cells. Methods of ATP production vary between cell types and cellular activation states. Glucose can be used to fuel ATP production through two linked metabolic pathways: glycolysis and the TCA cycle. In glycolysis, glucose is converted into pyruvate in the cytoplasm and phosphates are transferred to ADP to generat...

Similarities in the Metabolic Reprogramming of Immune System and Endothelium

Cellular metabolism has been known for its role in bioenergetics. In recent years, much light has been shed on the reprogrammable cellular metabolism underlying many vital cellular processes, such as cell activation, proliferation, and differentiation. Metabolic reprogramming in immune and endothelial cells (ECs) is being studied extensively. These cell compartments are implicated in inflammati...

inflammation in metabolic syndrome: role of adipose tissue

metabolic syndrome is a chronic low-grade inflammation condition which is associated with central obesity, dyslipidemia, insulin resistance and hypertension. inflammation in metabolic syndrome is not only associated with elevated serum inflammatory markers, such as c-reactive protein (crp), but also, is associated with low-grade inflammation in adipose tissue and releasing of adipokines. higher...