Method Development for the Quantitative Analysis of Multivitamin Supplements by Laser Ablation–Inductively Coupled Plasma–Mass Spectrometry (LA-ICP-MS)

We present the development and optimization of an analytical method based on Laser Ablation–Inductively Coupled Plasma–Mass Spectrometry (LA-ICP-MS) for analysis multivitamin dietary supplements. Samples were ground mixed with a cellulose powder containing internal standard elements; resulting was pressed into pellets. Two calibration strategies compared: (1) using increasing mass fractions fortified multiple elements interest (2) matrix matching reference material in addition to multi-element powder. ICP-MS parameters closely monitored achieve optimal conditions monitoring multivitamins while reducing variability between replicate measurements. An energy output 0.5 J/cm2, repetition rate 30 Hz, He carrier gas flow 800 mL/min provided best compromise sensitivity reproducibility. These produced most similar ablation behavior matrix-matched strategy. The dissimilarities yield due differences focus surface samples successfully corrected after normalizing standard, relative less than 10%. results from two different approaches compared those obtained solution-based Inductively Plasma–Optical Emission Spectroscopy (ICP-OES) analyses. For multivitamins, both methods (i.e., calibrations) performed adequately As, B, Co, Cr, Cu, Mg, Ni, Na, Pb, Zn. Matrix-matched additionally resulted better recoveries S Fe. Overall, more comparison calibration.