Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1)
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چکیده
منابع مشابه
Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1).
Numerous studies indicate that Sirtuin 1 (SIRT1), a mammalian nicotinamide adenine dinucleotide (NAD(+))-dependent histone deacetylase (HDAC), plays a crucial role in p53-mediated stress responses by deacetylating p53. Nevertheless, the acetylation levels of p53 are dramatically increased upon DNA damage, and it is not well understood how the SIRT1-p53 interaction is regulated during the stress...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2011
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1019619108