Mex3c regulates insulin-like growth factor 1 (IGF1) expression and promotes postnatal growth

Mex3c regulates insulin-like growth factor 1 (IGF1) expression and promotes postnatal growth

Insulin-like growth factor 1 (IGF1) mediates the growth-promoting activities of growth hormone. How Igf1 expression is regulated posttranscriptionally is unclear. Caenorhabditis elegans muscle excess 3 (MEX-3) is involved in cell fate specification during early embryonic development through regulating mRNAs involved in specifying cell fate. The function of its mammalian homologue, MEX3C, is unk...

LMP1 promotes expression of insulin-like growth factor 1 (IGF1) to selectively activate IGF1 receptor and drive cell proliferation.

UNLABELLED Epstein-Barr Virus (EBV) is a gammaherpesvirus that infects the majority of the human population and is linked to the development of multiple cancers, including nasopharyngeal carcinoma. Latent membrane protein 1 (LMP1) is considered the primary oncoprotein of EBV, and in epithelial cells it induces the expression and activation, or phosphorylation, of the epidermal growth factor rec...

English as the universal language of science: opportunities and challenges

Mex3c regulates insulin-like growth factor 1 (IGF1) expression and promotes postnatal growth Y. Jiao, C. E. Bishop, and B. Lu 1404–1413 Mex3c is highly expressed in the testis, brain, and developing bone. Mex3c mutation causes postnatal growth retardation and background-dependent perinatal lethality, possibly through impairing the translation of insulin-like growth factor 1 mRNA in bone-forming...

Insulin-Like Growth Factor 1 Promotes Cord

Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth.

To examine the relationship between growth hormone (GH) and insulin-like growth factor 1 (IGF1) in controlling postnatal growth, we performed a comparative analysis of dwarfing phenotypes manifested in mouse mutants lacking GH receptor, IGF1, or both. This genetic study has provided conclusive evidence demonstrating that GH and IGF1 promote postnatal growth by both independent and common functi...