MIB-1 Proliferation Index Predicts Survival among Patients with Grade II Astrocytoma

Pilomyxoid astrocytoma with high proliferation index

Pilomyxoid astrocytomas is an uncommon aggressive piloid neoplasm, closely related to pilocytic astrocytomas and typically presents in the very young but can occur in older children and rarely in adults. A 12-years-old male presented with focal seizures, headache and vomiting of 10 days duration. Computed tomogram showed a hypo- to hyperdense and peripherally enhancing, solid-cystic lesion in t...

Cytologic grade independently predicts survival of patients with pancreatic adenocarcinoma.

Our objectives were to devise a cytologic grading system and determine whether it would predict survival of patients with solid-type pancreatic adenocarcinoma. We evaluated 116 consecutive patients from July 2000 to November 2002; they were followed up until September 2003. We scored the following features on rapid Romanowsky-stained endoscopic ultrasound-guided fine-needle aspiration smears: c...

Patterns of failure after multimodal treatments for high-grade glioma: effectiveness of MIB-1 labeling index

BACKGROUND The purpose of the present study was to analyze the recurrence pattern of high-grade glioma treated with a multimodal treatment approach and to evaluate whether the MIB-1 labeling index (LI) could be a useful marker for predicting the pattern of failure in glioblastoma (GB). METHODS AND MATERIALS We evaluated histologically confirmed 131 patients with either anaplastic astrocytoma ...

Use of Bayes rule and MIB-1 proliferation index to discriminate Spitz nevus from malignant melanoma.

Differentiating Spitz nevus from malignant melanoma is difficult and controversial. Despite helpful lists of differential diagnostic features, uncertainty about the diagnosis often provokes some to stain the tumor for MIB-1 antibody to Ki-67 and measure the proliferation index (PI) of the tumor. Of the many reports about MIB-1 PI in Spitz nevi and melanoma, none have consolidated the informatio...

Mitotic activity is associated with a shorter survival and is used as a grading criterion to distinguish infiltrating astrocytoma, WHO grade II from anaplastic astrocytoma, WHO grade III. Likewise, necrosis and microvascular proliferation signal