Mice with Impaired Extrathyroidal Thyroxine to 3,5,3′-Triiodothyronine Conversion Maintain Normal Serum 3,5,3′-Triiodothyronine Concentrations
نویسندگان
چکیده
منابع مشابه
The extrathyroidal conversion rate of thyroxine to triiodothyronine in normal man.
Eight normal subjects were administered tracer amounts of a (14)C-labeled thyroxine, L-[tyrosyl-(14)C] T(4), by multiple injections. Then serial blood samples were collected for isolation of the thyroxine, triiodothyronine, and tetraiodothyroacetic acid fractions by a combination of column and paper chromatographies. The chromatographic artifacts were corrected by adding to the sera a purified ...
متن کاملPropylthiouracil blocks extrathyroidal conversion of thyroxine to triiodothyronine and augments thyrotropin secretion in man.
Propylthiouracil (PTU) inhibits peripheral deiodination of thyroxine (T4) and triiodothyronine (T3) and decreases the metabolic effectiveness of T4 in animals. To assess the effect of PTU on extrathyroidal conversion of T4 to T3 in man, 15 studies were performed in athyreotic patients treated with 100 or 200 mug of L-T4 daily for 1 mo before the addition of PTU, 250 mg every 6 h for 8 days. se...
متن کاملSerum free thyroxine and free triiodothyronine concentrations in pregnancy.
Blood was taken from women in each trimester of pregnancy at routine antenatal visits. Further samples were collected from an age matched control group of euthyroid women taking no medication. Free triiodothyronine and free thyroxine concentrations were measured by direct radioimmunoassay (Amerlex Kit methods, Amersham International, Amersham, Buckinghamshire).2 These free hormone assays use th...
متن کاملHepatic failure resulting from thyroid storm with normal serum thyroxine and triiodothyronine concentrations.
A 63-year-old male presented with productive cough, fever, palpitation, shortness of breath, and mental confusion. Fulminant hepatic failure occurred with high aminotransferase and severe jaundice. Thyroid function tests showed thyroid-stimulating hormone level of 0.7 microU/mL (normal range, < 6.2 microU/mL), with normal serum thyroxine and triiodothyronine levels. He died on post-admission da...
متن کاملLevothyroxine therapy and serum free thyroxine and free triiodothyronine concentrations.
Although the normal thyroid gland secretes both levothyroxine (L-T4) and levotriiodothyronine (L-T3), normalization of serum TSH with L-T4-replacement therapy alone in hypothyroidism is generally believed to result in a normal serum L-T3 and to reflect a euthyroid state. However several recent studies suggest that this may not be the case. Accordingly, the relationship between serum free L-T4 a...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2007
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2006-1042