Microsomal Membrane and Drug Oxidizing Enzyme System
نویسندگان
چکیده
منابع مشابه
Hepatic Microsomal Alcohol-oxidizing System
Oxidation of methanol, ethanol, propanol, and butanol by the microsomal fraction of rat liver homogenate is described. This microsomal alcohol-oxidizing system is dependent on NADPH and molecular oxygen and is partially inhibited by CO, features which are commori for microsomal drug-metabolizing enzymes. The activity of the microsomal alcohol-oxidizing system could be dissociated from the alcoh...
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An ethanol-oxidizing system was reconstituted with cytochrome P-450, NADPH-cytochrome r reductase, and phospholipid. This system also metabolized propanol, butanol, and benzphetamine. Neither catalase nor alcohol dehydrogenase plays a role in this system. Characteristics of this system are similar to those of the microsomal ethanoloxidizing system. Chronic ethanol feeding of either male or fema...
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We have proposed that glucose-6.phosphatase (EC 3.1.3.9) is a two-component system consisting of (a) a glucose-6-P-specific transporter which mediates the movement of the hexose phosphate from the cytosol to the lumen of the endoplasmic reticulum (or cisternae of the isolated microsomal vesicle), and (b) a nonspecific phosphohydrolase-phosphotransferase localized on the luminal surface of the m...
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The oxidation of various inositols (hexahydroxycyclohexanes) and quercitols (pentahydroxycyclohexanes) and their derivatives by resting cells of Acetobacter suboxydans has been studied by Chargaff and his students (1, 2), who found that the specificity exhibited by the organism toward the cyclitols studied was not adequately described by the Bertrand-Hudson rules (3) for open chain polyalcohols...
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A hepatic microsomal ethanol-oxidizing system is described both in men and rats. It is distinguished from alcohol dehydrogenase by its subcellular localization (cytosol for alcohol dehydrogenase, microsomes for this system), its pH optimum (physiological pH versus pH 10 to 11 for alcohol dehydrogenase), and its cofactor requirements (NADPH versus NAD+ for alcohol dehydrogenase). It also require...
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ژورنال
عنوان ژورنال: RADIOISOTOPES
سال: 1976
ISSN: 1884-4111,0033-8303
DOI: 10.3769/radioisotopes.25.8_487