Microtubule Active Agents: Beyond the Taxane Frontier
نویسندگان
چکیده
منابع مشابه
Microtubule active agents: beyond the taxane frontier.
Microtubules are essential to cell transport, signaling, and mitosis. An increasing range of anticancer drugs interferes with the normal formation and function of microtubules. Vinca alkaloids act as microtubule destabilizers and the taxanes act as microtubule stabilizers. Taxanes are widely used cytotoxic agents that are active in a range of solid tumor malignancies and are routinely used in a...
متن کاملBeyond Frontier Exploration
This article investigates the prerequisites for a global exploration strategy in an unknown environment on a virtual disaster site. Assume that a robot equipped with a laser range scanner can build a detailed map of a previous unknown environment. The remaining question is how to use this information on this map for further exploration. On a map several interesting locations can be present wher...
متن کاملMicrotubule-Associated Protein Expression and Predicting Taxane Response PRINCIPAL INVESTIGATOR:
The views, opinions and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of the Army position, policy or decision unless so designated by other documentation. Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing...
متن کاملEphrinB1: novel microtubule associated protein whose expression affects taxane sensitivity
Microtubules (MTs) are components of the cytoskeleton made up of polymerized alpha and beta tubulin dimers. MT structure and function must be maintained throughout the cell cycle to ensure proper execution of mitosis and cellular homeostasis. The protein tyrosine phosphatase, PTPN13, localizes to distinct compartments during mitosis and cytokinesis. We have previously demonstrated that the HPV1...
متن کاملZoonoses Frontier: Veterinarian, Producer, Processor and Beyond
24 As many emerging and re-emerging infectious diseases are associated with food 25 animals, the relationship between available healthy food sources and population 26 health and social stability has become evident. A recent example of the importance of 27 this relationship was observed during the current flu pandemic. This recent pandemic 28 brought attention to novel target groups of susceptib...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2008
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-08-0169