Microwave-assisted one pot three-component synthesis of some novel pyrazole scaffolds as potent anticancer agents

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Microwave-assisted one pot three-component synthesis of some novel pyrazole scaffolds as potent anticancer agents

BACKGROUND Pyrazoles, thiazoles and 1,3,4-thiadiazoles have been reported to possess various pharmacological activities. RESULTS An efficient and a novel approach for the synthesis of some novel pyrazole based-azoles are described via multi-component reaction under controlled microwave heating conditions. The structures of the synthesized compounds were assigned on the basis of elemental anal...

متن کامل

Microwave-assisted Synthesis of Acridine-1,8(2H,5H)-diones via a One-pot, Three Component Reaction

A new and improved protocol for the synthesis, in good to excellent yields, of acridine-1,8(2H,5H)-diones is described, involving a one-pot, three component reaction of dimedone, arylglyoxals, and ammonium acetate in water under microwave irradiation.  

متن کامل

Microwave assisted one pot synthesis of some pyrazole derivatives as a safer anti-inflammatory and analgesic agents.

A series of pyrazolo[3,4-b]quinolines have been synthesized using one-pot water mediated synthetic route under microwave irradiation involving the condensation of 2-chloroquinoline-3-carbaldehydes with semicarbazide or 2,4-dinitrophenyl hydrazine. The compounds were evaluated for their anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation actions. The pharmacological evaluation showe...

متن کامل

One-pot Three-component Synthesis of Phosphonate Derivatives

The stable phosphonate derivatives have easily synthesized by the reactions involving trialkyl(aryl) phosphites and dimethyl acetylenedicarboxylate in the presence of 4-nitrophenol and/or acid chlorides, dialkyl(aryl) phosphites and N-methylimidazole at 70 oC under solventfree conditions.

متن کامل

A novel microwave-mediated one-pot synthesis of indolizines via a three-component reaction.

[reaction: see text] The microwave-mediated three-component reaction of acyl bromide, pyridine, and acetylene is catalyzed by basic alumina to give corresponding indolizines in excellent yields in a one-pot reaction.

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Chemistry Central Journal

سال: 2017

ISSN: 1752-153X

DOI: 10.1186/s13065-017-0266-4