MIF magnifies malarial anemia
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منابع مشابه
MIF magnifies malarial anemia
Mast cells that accumulate cholesterol precursors in their membranes tend to overreact, according to Kovarova and colleagues on page 1161. This mast cell hyperresponsiveness might help explain why patients with a genetic disease known as Smith-Lemli-Opitz syndrome (SLOS) are prone to food allergies. Patients with SLOS have abnormally low levels of circulating cholesterol— and a corresponding ab...
متن کاملMIF (macrophage migration inhibitory factor) promoter polymorphisms and susceptibility to severe malarial anemia.
BACKGROUND Severe malarial anemia (SMA) resulting from Plasmodium falciparum infection is one of the leading causes of childhood mortality in sub-Saharan Africa. The innate immune mediator macrophage migration inhibitory factor (MIF) plays a critical role in the pathogenesis of SMA. METHODS To investigate the influence of MIF genetic variation on susceptibility to SMA, haplotypes of the MIF -...
متن کاملMalarial anemia and STAT6.
M alaria infection places a huge economic burden on the developing world. It has been estimated that annually there are over 500 million episodes and it is responsible for 18% of childhood deaths in sub-Saharan Africa. 1 Infection in the human host is initiated by a bite from a female anopheline mosquito during which sporozoites enter the body and home to the liver initiating the hepatic phase ...
متن کاملSevere Malarial Anemia: Innate Immunity and Pathogenesis
Greater than 80% of malaria-related mortality occurs in sub-Saharan Africa due to infections with Plasmodium falciparum. The majority of P. falciparum-related mortality occurs in immune-naïve infants and young children, accounting for 18% of all deaths before five years of age. Clinical manifestations of severe falciparum malaria vary according to transmission intensity and typically present as...
متن کاملMalarial anemia: of mice and men.
Severe malaria is manifest by a variety of clinical syndromes dependent on properties of both the host and the parasite. In young infants, severe malarial anemia (SMA) is the most common syndrome of severe disease and contributes substantially to the considerable mortality and morbidity from malaria. There is now growing evidence, from both human and mouse studies of malaria, to show that anemi...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2006
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.2035iti1