Mifepristone modulates serotonin transporter function
نویسندگان
چکیده
منابع مشابه
The Serotonin Transporter and Platelet Function
August 2010 Volume 10, Issue 4 T he serotonin transporter (SERT) on platelets is a primary mechanism for serotonin (5HT) uptake from the blood plasma. Alteration in plasma 5HT level is associated with a number of cardiovascular diseases and disorders. Therefore, the regulation of the transporter’s activity represents a key mechanism to stabilize the concentration of plasma 5HT. There is a bipha...
متن کاملSerotonin transporter genotype modulates amygdala activity during mood regulation.
Recent studies have implicated the short allele of the serotonin transporter-linked polymorphic region (5-HTTLPR) in depression vulnerability, particularly in the context of stress. Several neuroimaging studies have shown that 5-HTTLPR genotype predicts amygdala reactivity to negatively valenced stimuli, suggesting a mechanism whereby the short allele confers depression risk. The current study ...
متن کاملCautionary note: complex (dys) function of the serotonin transporter.
To the Editor: Reduced binding to the serotonin transporter (5-HTT) in unaffected relatives of patients with manic– depressive illness has been recently reported as a hint of a putative trait marker for the disease by Leboyer et al (1999). We offer a few comments and views on this. First, the fashion by which individuals in the population differ from each other for some parameters indicative of...
متن کاملStructure, function and regulation of the 5-hydroxytryptamine (serotonin) transporter.
The serotonin transporter (SERT), which terminates serotonergic neurotransmission by rapid re-uptake of 5-hydroxytryptamine (5-HT) back into the nerve terminal was the subject of two studies. First, the regulatory effects of antidepressants on the expression of SERT was investigated. After chronic exposure of SERT to antidepressants, substrate transport and antidepressant binding parameters wer...
متن کاملPlatelet Serotonin Transporter Function Predicts Default-Mode Network Activity
BACKGROUND The serotonin transporter (5-HTT) is abundantly expressed in humans by the serotonin transporter gene SLC6A4 and removes serotonin (5-HT) from extracellular space. A blood-brain relationship between platelet and synaptosomal 5-HT reuptake has been suggested, but it is unknown today, if platelet 5-HT uptake can predict neural activation of human brain networks that are known to be und...
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ژورنال
عنوان ژورنال: Neural Regeneration Research
سال: 2014
ISSN: 1673-5374
DOI: 10.4103/1673-5374.130112