miR-3151 interplays with its host gene BAALC and independently affects outcome of patients with cytogenetically normal acute myeloid leukemia
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چکیده
منابع مشابه
Plenary paper miR-3151 interplays with its host gene BAALC and independently affects outcome of patients with cytogenetically normal acute myeloid leukemia
Ann-Kathrin Eisfeld,1 Guido Marcucci,1 Kati Maharry,1,2 Sebastian Schwind,1 Michael D. Radmacher,1,2 Deedra Nicolet,1,2 Heiko Becker,1 Krzysztof Mrózek,1 Susan P. Whitman,1 Klaus H. Metzeler,1 Jason H. Mendler,1 Yue-Zhong Wu,1 Sandya Liyanarachchi,1 Ravi Patel,1 Maria R. Baer,3 Bayard L. Powell,4 Thomas H. Carter,5 Joseph O. Moore,6 Jonathan E. Kolitz,7 Meir Wetzler,8 Michael A. Caligiuri,1 Ric...
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BACKGROUND Mutations occur in several genes in cytogenetically normal acute myeloid leukemia (AML) cells: the nucleophosmin gene (NPM1), the fms-related tyrosine kinase 3 gene (FLT3), the CCAAT/enhancer binding protein alpha gene (CEPBA), the myeloid-lymphoid or mixed-lineage leukemia gene (MLL), and the neuroblastoma RAS viral oncogene homolog (NRAS). We evaluated the associations of these mut...
متن کاملEvaluation of BAALC gene expression in normal cytogenetic acute myeloid leukemia patients in north-east of Iran
Background: Acute myeloid leukemia (AML) is known as one of the most common leukemia among adults. Environmental and different genetic factors affect disease process, prognosis and treatment. Among different genetic factors NPM1, FLT3, MLL and BAALC genes are the most effective on patient's survival rate. The aim of this study was to assess amount of BAALC gene expression in AML patients, and i...
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OBJECTIVE This study aimed to assess the prognostic impact of Wilms tumor 1 (WT1) mutations in cytogenetically normal acute myeloid leukemia (CN-AML) among Egyptian patients. MATERIALS AND METHODS Exons 1, 2, 3, 7, 8, and 9 of WT1 were screened for mutations in samples from 82 CN-AML patients out of 203 newly diagnosed AML patients, of age ranging from 21 to 74 years, using high-resolution ca...
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1Division of Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH; 2Department of Microbiology, Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH; 3The Cancer and Leukemia Group B Statistical Center, Duke University Medical Center, Durham, NC; 4The Comprehensi...
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ژورنال
عنوان ژورنال: Blood
سال: 2012
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2012-02-408492