Mitochondrial apoptosis is amplified through gap junctions
نویسندگان
چکیده
منابع مشابه
Gap junctions: Getting the message through
Connexin proteins make intercellular channels - gap junctions - which provide a direct pathway for cell-cell signaling in vertebrates. Studies of mice lacking connexin genes have demonstrated the need for intercellular transfer of messenger molecules and are uncovering the specific functions of each connexin.
متن کاملMetabolic trafficking through astrocytic gap junctions.
Astrocytes are interposed between the pericapillary space and neuronal membranes. Consequently, they may represent an important intermediary element between the source of energetic substrates and the main site of energy-consuming elements, respectively, the blood circulation and the neurons. A typical feature of astrocytes is the connections they establish between each other by specialized memb...
متن کاملGap Junctions
Gap junctions are sites of intercellular communication where cells are interconnected by small aqueous channels (Figure 1b). The term is morphological, for in transmission electron micrographs of thin sections, the unit membranes of the joined cells are seen to remain separated by a gap of about 2 nm (Figure 1a, inset). The gap of gap junctions distinguishes them from tight junctions, or zonula...
متن کاملGap junctions
In vertebrates and invertebrates, signaling among neurons is most commonly mediated by chemical synapses. At these synapses neurotransmitter released by presynaptic neurons is detected by receptors on the postsynaptic neurons, leading to an influx of ions through the receptors themselves or through channels activated by intracellular signaling downstream of the receptors. But neurons can commun...
متن کاملAxonal Gap Junctions Send Ripples through the Hippocampus
In a paper by Schmitz and colleagues in this issue of Neuron, new evidence for the existence of gap junctions between pyramidal cell axons uncovers a mechanism for fast neural communication in the hippocampus. Electrical coupling between axons may be crucial during fast oscillations, which have been proposed to mediate memory consolidation.
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 2009
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2009.09.054