Mitochondrial ROMK Channel Is a Molecular Component of MitoK ATP

The Mitochondrial ROMK Channel is a Molecular Component of MitoKATP

Authors contributed equally to this work.

Integrative Physiology Mitochondrial ROMK Channel Is a Molecular Component of MitoKATP

A new pROM king for the mitoK(ATP) dance: ROMK takes the lead.

Ischemic heart disease remains the leading cause of death in the developed world, and mechanisms to reduce cardiac ischemic damage are being actively investigated. A potent protective mechanism for the heart is ischemic preconditioning (IPC), a phenomenon in which brief ischemic episodes protect the heart from tissue damage and cell death resulting from subsequent periods of ischemia and reperf...

Sequencing and Molecular Analysis of ATP 6 and ATP 8 of Mitochondrial Genome in Khorasanian Native Chickens

In order to perform breeding programs and improve production of native chickens, preserving genetic diversity in different areas of Iran is important due to the reduced available population. Genome sequencing is considered the most functional approach to determine the phylogeny relation between close populations. The aim of the present study was the evaluation of the phylogeny and genetic nucle...

A novel mitochondrial K(ATP) channel assay.

RATIONALE The mitochondrial ATP sensitive potassium channel (mK(ATP)) is implicated in cardioprotection by ischemic preconditioning (IPC), but the molecular identity of the channel remains controversial. The validity of current methods to assay mK(ATP) activity is disputed. OBJECTIVE We sought to develop novel methods to assay mK(ATP) activity and its regulation. METHODS AND RESULTS Using a...