Mitosis: Riding the Protofilament Curl
نویسندگان
چکیده
منابع مشابه
Mitosis: Riding the Protofilament Curl
More than 50 years ago, microtubule depolymerization was proposed as the force responsible for chromosome movement. New studies measure the force produced by depolymerization and show that protein ring complexes can couple depolymerization to movement. These results have implications for anaphase chromosome motility and mitotic evolution.
متن کاملKinesin follows the microtubule's protofilament axis
We tested the hypothesis that kinesin moves parallel to the microtubule's protofilament axis. We polymerized microtubules with protofilaments that ran either parallel to the microtubule's long axis or that ran along shallow helical paths around the cylindrical surface of the microtubule. When gliding across a kinesin-coated surface, the former microtubules did not rotate. The latter microtubule...
متن کاملThe protofilament structure of insulin amyloid fibrils.
Under solution conditions where the native state is destabilized, the largely helical polypeptide hormone insulin readily aggregates to form amyloid fibrils with a characteristic cross-beta structure. However, there is a lack of information relating the 4.8 A beta-strand repeat to the higher order assembly of amyloid fibrils. We have used cryo-electron microscopy (EM), combining single particle...
متن کاملMicrotubule catastrophe from protofilament dynamics.
The disappearance of the guanosine triphosphate- (GTP) tubulin cap is widely believed to be the forerunner event for the growth-shrinkage transition ("catastrophe") in microtubule filaments in eukaryotic cells. We study a discrete version of a stochastic model of the GTP cap dynamics, originally proposed by Flyvbjerg, Holy, and Leibler [Phys. Rev. Lett. 73, 2372 (1994)]. Our model includes both...
متن کاملLocal Fourier Analysis of Multigrid for the Curl-Curl Equation
We present a local Fourier analysis of multigrid methods for the two-dimensional curl-curl formulation of Maxwell's equations. Both the hybrid smoother proposed by Hiptmair and the overlapping block smoother proposed by Arnold, Falk and Winther are considered. The key to our approach is the identification of two-dimensional eigenspaces of the discrete curl-curl problem by decou-pling the Fourie...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Biology
سال: 2006
ISSN: 0960-9822
DOI: 10.1016/j.cub.2006.02.025