Mixed-phenotypic acute leukemia: cytochemically myeloid and phenotypically early T-cell precursor acute lymphoblastic leukemia
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چکیده
منابع مشابه
Mixed-phenotypic acute leukemia: cytochemically myeloid and phenotypically early T-cell precursor acute lymphoblastic leukemia
TO THE EDITOR: Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is characterized by the specific immunophenotype of CD1a, CD8, and CD5 with stem cell or myeloid marker expression. This leukemia presents a particular flow cytometric diagnostic challenge, as it frequently exhibits sufficient myeloid-lineage differentiation to be classified as mixed-phenotype acute leukemia (MPAL). Th...
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Discrete diagnostic subtypes of T lymphoblastic leukemia/lymphoma (T-cell acute lymphoblastic leukemia/lymphoma, T-ALL) have historically not been widely recognized. Recently, a novel subset with distinctive immunophenotypic, molecular, and clinical features has been proposed. Termed early T-cell precursor acute lymphoblastic leukemia (ETP-ALL), these cases seem to correspond to a very early st...
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A 15-year-old boy presented at our center with shortness of breath and swelling in the neck since 4 months. On examination he had hepatosplenomegaly and generalized lymphadenopathy. Clinically, acute lymphoblastic leukemia, possibly T-cell lineage was considered. His hemogram showed a hemoglobin level of 56 gm/L, total leukocyte count of 3.4 10/L, platelets of 105 10/L, and 50% circulating blas...
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ژورنال
عنوان ژورنال: Blood Research
سال: 2014
ISSN: 2287-979X,2288-0011
DOI: 10.5045/br.2014.49.3.196