Mo1880 – Ulcerative Colitis Patients are Characterized by a Decreased Frequency of Systemic Gpr15+ Innate Lymphoid Cells
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چکیده
منابع مشابه
Differential expression of GPR15 on T cells during ulcerative colitis.
G protein-coupled receptor 15 (GPR15) was recently highlighted as a colon-homing receptor for murine and human CD4+ T cells. The aim of this study was to explore the functional phenotype of human GPR15+CD4+ T cells, focusing on Tregs and effector T cells (Teffs), and to determine whether GPR15 is the driver for the migration of T cells to the colon during ulcerative colitis (UC). In the periphe...
متن کاملThe systemic complications of ulcerative colitis.
Incidence The frequency of various systemic complications of ulcerative colitis was studied in the series of 465 patients investigated in Leeds between 1948 and 1963 by de Dombal and his colleagues. Skin lesions occurred in twenty-nine patients (6 2%), colitic arthritis in fifty-six patients (12-0%), sacro-iliitis in forty-two patients (18%) and florid spondylitis in thirteen patients (6%). Eye...
متن کاملSURGICAL TREATMENT OF ULCERATIVE COLITIS
This is a preliminary report of 28 patients with ulcerative colitis who we surgically treated with "J" pouch endorectal pull-through operation from 1978 to 1996. All patients are continent with a median stool frequency of 4 times per day, no night soilage. low postoperative complications and one mortality due to pulmonary embolism.
متن کاملInnate lymphoid cells
Purpose of review: The purpose of this article is to review recent advances in our understanding of innate lymphoid cell function and to speculate on how these cells may become activated and influence the immune response to allogeneic tissues and cells following transplantation. Recent findings: Innate lymphoid cells encompass several novel cell types whose wide ranging roles in the immune syst...
متن کاملHuman innate lymphoid cells.
Innate lymphoid cells (ILCs) are lymphoid cells that do not express rearranged receptors and have important effector and regulatory functions in innate immunity and tissue remodeling. ILCs are categorized into 3 groups based on their distinct patterns of cytokine production and the requirement of particular transcription factors for their development and function. Group 1 ILCs (ILC1s) produce i...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 2019
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(19)39147-4