Model Selection and the Molecular Clock
نویسندگان
چکیده
منابع مشابه
Model Selection and the Molecular Clock
T here are no mathematical equations in On the Origin of Species. A good thing too, you might think, and it is undoubtedly true that Darwin's clear and fl owing narrative style helped ensure the popularity of his writings. Modern research in evolutionary biology can make for less easy reading. Much of it concerns the development of an expanding arsenal of mathematical and statistical techniques...
متن کاملNatural selection and the molecular clock.
This paper concludes that the statistical properties of protein evolution are compatible with a particular model of evolution by natural selection. The argument begins with a statistical description of the molecular clock based on a Poisson process with a randomly varying tick rate. If the time scale of the change of the tick rate of the molecular clock is assumed to be much less than the avera...
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There is currently no calibration available for the whole human mtDNA genome, incorporating both coding and control regions. Furthermore, as several authors have pointed out recently, linear molecular clocks that incorporate selectable characters are in any case problematic. We here confirm a modest effect of purifying selection on the mtDNA coding region and propose an improved molecular clock...
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Rates of molecular evolution at some loci are more irregular than described by simple Poisson processes. Three situations under which molecular evolution would not follow simple Poisson processes are reevaluated from the viewpoint of the neutrality hypothesis: concomitant or multiple substitutions in a gene, fluctuating substitution rates in time caused by coupled effects of deleterious mutatio...
متن کاملVagaries of the molecular clock.
The hypothesis of the molecular evolutionary clock asserts that informational macromolecules (i.e., proteins and nucleic acids) evolve at rates that are constant through time and for different lineages. The clock hypothesis has been extremely powerful for determining evolutionary events of the remote past for which the fossil and other evidence is lacking or insufficient. I review the evolution...
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ژورنال
عنوان ژورنال: PLoS Biology
سال: 2006
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.0040151