Modeling crawling cell movement on soft engineered substrates

Modeling crawling cell movement on soft engineered substrates.

Self-propelled motion, emerging spontaneously or in response to external cues, is a hallmark of living organisms. Systems of self-propelled synthetic particles are also relevant for multiple applications, from targeted drug delivery to the design of self-healing materials. Self-propulsion relies on the force transfer to the surrounding. While self-propelled swimming in the bulk of liquids is fa...

3-d cell modeling and investigating its movement on non-rigid substrates

introduction: attachment of blood and tissue cells to the extracellular matrix (ecm) is done with the help of specific joints, which are made between cells’ receptors and matrixes’ ligands. this interaction is vital for many biological activities such as cell migration, cancer development, and wound healing. the purpose of this study is to model a 3-dimensional cell by abaqus commercial softwar...

Selective modulation of cell response on engineered fractal silicon substrates

A plethora of work has been dedicated to the analysis of cell behavior on substrates with ordered topographical features. However, the natural cell microenvironment is characterized by biomechanical cues organized over multiple scales. Here, randomly rough, self-affinefractal surfaces are generated out of silicon,where roughness Ra and fractal dimension Df are independently controlled. The prol...

Soft-404 Pages, A Crawling Problem

During its traversal of the Web, crawler systems have to deal with multiple challenges. Some of them are related with detecting garbage content to avoid wasting resources processing it. Soft-404 pages are a type of garbage content generated when some web servers do not use the appropriate HTTP response code for death links making them to be incorrectly identified. Our analysis of the Web has re...

Modeling of Cell Motion on Patterned Adhesive and Deformable Substrates