Modeling Gene-Gene Interactions Using Graphical Chain Models

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Graphical simulation using chain models

This paper presents an extension of a previously described framework for the speci cation and manipulation of models of systems. This extension is particularly useful in the context of graphical simulation. The original framework and its extension include a convenient Application Programming Interface (API), and this paper provides examples of the use of this API in the context of graphical sim...

متن کامل

Interactive Analysis of Gene Interactions Using Graphical gaussian model

DNA microarray provides a powerful basis for analysis of gene expression. Data mining methods such as clustering have been widely applied to microarray data to link genes that show similar expression patterns. However, this approach usually fails to unveil gene-gene interactions in the same cluster. Association rule mining and loglinear models have been used for this purpose, but their inherent...

متن کامل

Identifying gene regulatory network rewiring using latent differential graphical models

Gene regulatory networks (GRNs) are highly dynamic among different tissue types. Identifying tissue-specific gene regulation is critically important to understand gene function in a particular cellular context. Graphical models have been used to estimate GRN from gene expression data to distinguish direct interactions from indirect associations. However, most existing methods estimate GRN for a...

متن کامل

Analysis of gene-gene interactions using gene-trait similarity regression.

OBJECTIVE Gene-gene interactions (G×G) are important to study because of their extensiveness in biological systems and their potential in explaining missing heritability of complex traits. In this work, we propose a new similarity-based test to assess G×G at the gene level, which permits the study of epistasis at biologically functional units with amplified interaction signals. METHODS Under ...

متن کامل

Modeling of Gene Regulatory Networks Using State Space Models

Computational Genomics is now becoming the growing area for researchers to decipher biology from genome sequences and related high throughput data. In the post genomic era, there is huge amount of genomic data available because of different advanced experimental technology like microarray technology, Chromatin immune-precipitation with array hybridization (ChIP-chip) etc. [1]. In order to analy...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Human Heredity

سال: 2007

ISSN: 0001-5652,1423-0062

DOI: 10.1159/000106061