Modeling Traumatic Brain Injury and Posttraumatic Epilepsy
نویسندگان
چکیده
منابع مشابه
Blood-Brain Barrier Breakdown Following Traumatic Brain Injury: A Possible Role in Posttraumatic Epilepsy
Recent animal experiments indicate a critical role for opening of the blood-brain barrier (BBB) in the pathogenesis of post-traumatic epilepsy (PTE). This study aimed to investigate the frequency, extent, and functional correlates of BBB disruption in epileptic patients following mild traumatic brain injury (TBI). Thirty-seven TBI patients were included in this study, 19 of whom suffered from P...
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In this week’s PLoS Medicine, Seena Fazel and colleagues report elevated risks for violent crime among patients with traumatic brain injury (TBI) as well as among those with epilepsy, compared to general population controls [1]. Among the major strengths of the study are the very large sample size, comprising the entire population of Sweden, and the follow-up of 35 years. The findings are of ma...
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Posttraumatic epilepsy is a major source of disability following traumatic brain injury (TBI) and a common cause of medically-intractable epilepsy. Previous attempts to prevent the development of posttraumatic epilepsy with treatments administered immediately following TBI have failed. Recently, the mammalian target of rapamycin complex 1 (mTORC1) pathway has been implicated in mechanisms of ep...
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ژورنال
عنوان ژورنال: Epilepsy Currents
سال: 2004
ISSN: 1535-7597,1535-7511
DOI: 10.1111/j.1535-7597.2004.44015.x