Modelling nifedipine photodegradation, photostability and actinometric properties
نویسندگان
چکیده
منابع مشابه
Antioxidant effects of photodegradation product of nifedipine.
Recently, increasing evidence suggests that the antihypertensive drug nifedipine acts as a protective agent for endothelial cells, and that the activity is unrelated to its calcium channel blocking. Nifedipine is unstable under light and reportedly decomposes to a stable nitrosonifedipine (NO-NIF). NO-NIF has no antihypertensive effect, and it has been recognized as a contaminant of nifedipine....
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Address correspondence to S. Carda Broch. endroflumethiazide (BMFT [RS]-3-phenylmethyl-3,4-dihydro-6-trif luoromethyl-2H1,2,4-benzothiadiazine-7-sulfonamide-1,1dioxide) is a potent diuretic drug extensively used for the treatment of hypertension and oedema that belongs to the thiazide family (1). BMFT is well absorbed from the gastrointestinal tract after oral administration and the absorption ...
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Nifedipine (NIF) a 1, 4-dihydropyridine calcium channel antagonist, undergoes photodegradation to nitroso analogues of dehydronifedipine (NDNIF) when exposed to sunlight. Photodegradation products of NIF have no clinical activity, so different formulations of NIF must remain unchanged. If NIF preparations become unstable in exposure to light, they could cause therapeutic failure. The present st...
متن کاملPhotostability Determination of Commercially Available Nifedipine Oral Dosage Forms in Iran
Nifedipine (NIF) a 1, 4-dihydropyridine calcium channel antagonist, undergoes photodegradation to nitroso analogues of dehydronifedipine (NDNIF) when exposed to sunlight. Photodegradation products of NIF have no clinical activity, so different formulations of NIF must remain unchanged. If NIF preparations become unstable in exposure to light, they could cause therapeutic failure. The present st...
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Fibras de bagaço de cana-de-açúcar não alvejadas (FBC) e alvejadas com peróxido de hidrogênio (FBC-AP) foram enxertadas com o absorvedor de UV hidroxifenilbenzotriazol (1) e/ou com um radical nitróxido do tipo piperidiniloxi (3). As fibras FBC-AP foram também acetiladas com anidrido acético. A fotossensibilidade dessas fibras à radiação UV foi avaliada comparativamente, empregando coordenadas L...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutics
سال: 2013
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2013.07.075