Modern view on hepatic encephalopathy: basic terms and concepts of pathogenesis
نویسندگان
چکیده
منابع مشابه
Pathogenesis of Hepatic Encephalopathy
Hepatic encephalopathy can be a serious complication of acute liver failure and chronic liver diseases, predominantly liver cirrhosis. Hyperammonemia plays the most important role in the pathogenesis of hepatic encephalopathy. The brain-blood barrier disturbances, changes in neurotransmission, neuroinflammation, oxidative stress, GABA-ergic or benzodiazepine pathway abnormalities, manganese neu...
متن کاملThe pathogenesis of hepatic encephalopathy.
Hepatic encephalopathy remains a complex clinicopathological problem. Much is known about the biochemical derangements in liver, blood, and brain. The precise pathogenetic mechanism for central nervous system dysfunction remains to be determined. Ammonia continues to be considered as an important neurotoxin and may act synergistically with other toxic substances. Disturbances of amino acid bala...
متن کاملHepatic encephalopathy: etiology, pathogenesis, and clinical signs.
Hepatic encephalopathy (HE) is a manifestation of clinical signs that may result from a variety of liver diseases. In small animals, HE is most commonly a result of portosystemic shunting. The pathogenesis is not completely understood, although it is likely multifactorial. Theories of pathogenesis include altered ammonia metabolism and glutamine and glutamate transmission, an increase in gamma-...
متن کاملHepatic Encephalopathy — Definition, Pathogenesis and Clinical Features
The former is a sequel of acute viral hepatitis A and B, toxic hepatitis as a result of severe poisoning with hazardous substances or rapid blockage of the liver blood supply, while the latter one is an after-effect of chronic hepatitis B, C and autoimmune hepatitis, longterm alcohol abuse, disordered bile outflow, certain drugs administration, non-alcoholic fatty liver disease (NAFLD) and non-...
متن کاملThe molecular pathogenesis of hepatic encephalopathy.
Hepatic encephalopathy (HE) incorporates a spectrum of neuropsychiatric abnormalities seen in patients with liver dysfunction with a potential for full reversibility. Distinct syndromes are identified in acute liver failure and cirrhosis. Rapid deterioration in consciousness level and increased intracranial pressure that may result in brain herniation and death are a feature of acute liver fail...
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ژورنال
عنوان ژورنال: Pathologia
سال: 2017
ISSN: 2310-1237,2306-8027
DOI: 10.14739/2310-1237.2017.3.118773