Modified LDL activates JNK‐2 phosphorylation and colocalization with mitochondria
نویسندگان
چکیده
منابع مشابه
Immunohistochemical demonstration of enzymatically modified human LDL and its colocalization with the terminal complement complex in the early atherosclerotic lesion.
Treatment of low density lipoprotein (LDL) with degrading enzymes transforms the molecule to a moiety that is micromorphologically indistinguishable from lipoproteinaceous particles that are present in atherosclerotic plaques, and enzymatically modified LDL (E-LDL), but not oxidized LDL (ox-LDL), spontaneously activates the alternative complement pathway, as do lesion lipoprotein derivatives. F...
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During recent studies of oxidative phosphorylation in rat liver mitochondria (2, 3)) we observed that preparations isolated with meticulous care catalyzed a significant uptake of inorganic orthophosphate in the absence of any added substrate. Although incidental observations of endogenous activity of isolated mitochondria have been noted by others (P9), no extensive study of this phenomenon has...
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OBJECTIVES To explore possible associations of malondialdehyde-modified low-density lipoprotein (MDA-LDL) and LDL-immune complexes (LDL-IC) with atherosclerosis in rheumatoid arthritis (RA). DESIGN AND METHODS Plasma MDA-LDL, LDL-IC levels and mechanisms of the changes were investigated in RA patients with or without coronary artery disease (CAD), simple CAD patients and control. RESULTS MD...
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Department of Medicine, Medical University of South Carolina, Charleston, SC and Ralph A. Johnson VA Medical Center, Charleston, SC; The Biostatistics Center, George Washington University, Washington DC, Harvard Medical School and Massachusetts General Hospital, Boston, MA, Department of Microbiology and Immunology Department of Microbiology and Immunology, Medical University of South Carolina,...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2007
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.21.6.a853-c