Modular Isoquinoline Synthesis Using Catalytic Enolate Arylation and in Situ Functionalization
نویسندگان
چکیده
منابع مشابه
Modular Isoquinoline Synthesis Using Catalytic Enolate Arylation and in Situ Functionalization
A methyl ketone, an aryl bromide, an electrophile, and ammonium chloride were combined in a four-component, three-step, and one-pot coupling procedure to furnish substituted isoquinolines in overall yields of up to 80%. This protocol utilizes the palladium catalyzed α-arylation reaction of an enolate, followed by in situ trapping with an electrophile, and aromatization with ammonium chloride. t...
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ژورنال
عنوان ژورنال: Organic Letters
سال: 2013
ISSN: 1523-7060,1523-7052
DOI: 10.1021/ol4030309