Modulating the Immune Response in Periodontitis

Periodontitis is a chronic inflammatory condition initiated by the accumulation of bacterial biofilm. It highly prevalent and when left untreated can lead to tooth loss. The presence biofilm essential for initiation response but not sole initiator. Currently it unknown which mechanisms drive dysbiosis leading dysregulation response. Other players in this equation include environmental, systemic, genetic factors play role exacerbating Treatment periodontal disease consists removal with goal resolving response; however, does occur every case. Understanding way return state homeostasis has led investigators consider both systemic local pharmacological interventions. Nonetheless, better understanding impact that genetics environmental may have on could be key helping identify how inflammation modulated therefore stopping destruction periodontium. In article, we will explore current evidence associating microbial immune response, potential or pathways targeted modulation discuss advantages drawbacks associated management disease. This information valuable those interested adjunct methods managing diseases, limited to, dental professionals, clinical researchers public at large.