Modulation of cAMP-mediated differentiation in ovarian granulosa cells by epidermal growth factor and platelet-derived growth factor.

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Modulation of cAMP-mediated differentiation in ovarian granulosa cells by epidermal growth factor and platelet-derived growth factor.

The modulating actions of peptide growth factors on ovarian follicular maturation were studied in granulosa cells during CAMP-dependent differentiation induced by follicle-stimulating hormone (FSH). During a 48-h culture of granulosa cells from hypophysectomized diethylstilbestrol-treated immature rats, FSH induced a 100-fold rise in cAMP and progesterone accumulation and a Ibfold increase in l...

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 1983

ISSN: 0021-9258

DOI: 10.1016/s0021-9258(18)32787-x