Modulation of the skeletal muscle sodium channel α-subunit by the β1 -subunit
نویسندگان
چکیده
منابع مشابه
Crystallographic insights into sodium-channel modulation by the β4 subunit.
Voltage-gated sodium (Nav) channels are embedded in a multicomponent membrane signaling complex that plays a crucial role in cellular excitability. Although the mechanism remains unclear, β-subunits modify Nav channel function and cause debilitating disorders when mutated. While investigating whether β-subunits also influence ligand interactions, we found that β4 dramatically alters toxin bindi...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1993
ISSN: 0014-5793
DOI: 10.1016/0014-5793(93)80871-q