Modulation of the T-type cardiac Ca channel by changes in proton concentration.

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Modulation of the T-type cardiac Ca channel by changes in proton concentration

Single-channel measurements and whole-cell experiments with the two suction electrode, voltage clamp technique were used to investigate the effects of external and internal proton concentrations on T-type Ca channels in heart muscle cells of the guinea pig. As in the L-type Ca channel, an increase in the external proton concentration decreases T-type currents, while external alkalinization enla...

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T-type Ca(2+) channel modulation by otilonium bromide.

Antispasmodics are used clinically to treat a variety of gastrointestinal disorders by inhibition of smooth muscle contraction. The main pathway for smooth muscle Ca(2+) entry is through L-type channels; however, there is increasing evidence that T-type Ca(2+) channels also play a role in regulating contractility. Otilonium bromide, an antispasmodic, has previously been shown to inhibit L-type ...

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BACKGROUND Volatile anesthetics exert their negative chronotropic and inotropic effects, in part by depressing the L- and T-type calcium channels. This study examines and compares the dose-dependent effects of isoflurane on atrial L- and T-type calcium currents (I(Ca,L) and I(Ca,T)) and ventricular I(Ca,L). METHODS Whole cell I(Ca) was recorded from enzymatically isolated guinea pig cardiomyo...

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ژورنال

عنوان ژورنال: Journal of General Physiology

سال: 1990

ISSN: 0022-1295,1540-7748

DOI: 10.1085/jgp.96.5.973