Modulation of Tissue Microenvironment Following Myocardial Infarction

Significant progress has been made in methods for cardiac repair and regeneration within the past few decades; however, diseased microenvironment of infarct remains a limitation efficacy therapies. A breadth research is currently aiming to reverse this environment, focusing on immunomodulation, scavenging oxidative species, increasing oxygen levels tissue, either directly using materials or therapy secondarily via angiogenesis neovascularization techniques. Herein, an overview current reversal infarcted tissue less-diseased state, biomaterials such as electrospun scaffolds, gels nanoparticles, stem cells, derived exosomes, drugs, bioactive molecules growth factors, provided. Often, combinations therapies are complementary induce superior response. Finally, brief summation recent clinical trials