MOLECULAR EVOLUTION OF PHOSPHOLIPASES A2 FROM VENOMS OF VIPERS
نویسندگان
چکیده
منابع مشابه
Secreted Phospholipases A2 from Animal Venoms in Pain and Analgesia
Animal venoms comprise a complex mixture of components that affect several biological systems. Based on the high selectivity for their molecular targets, these components are also a rich source of potential therapeutic agents. Among the main components of animal venoms are the secreted phospholipases A₂ (sPLA₂s). These PLA₂ belong to distinct PLA₂s groups. For example, snake venom sPLA₂s from E...
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To explore the venom diversity of Asian pit vipers, we investigated the structure and function of venom phospholipase A2 (PLA2) derived from two primitive tree vipers Trimeresurus puniceus and Trimeresurus borneensis. We purified six novel PLA2s from T. puniceus venom and another three from T. borneensis venom. All cDNAs encoding these PLA2s except one were cloned, and the molecular masses and ...
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ژورنال
عنوان ژورنال: Journal of Venomous Animals and Toxins
سال: 1997
ISSN: 0104-7930
DOI: 10.1590/s0104-79301997000200022