Molecular insights into execution of necroptosis
نویسندگان
چکیده
منابع مشابه
Actors of necroptosis scenario in cell\'s scene
Necroptosis, as a novel concept, has been recently introduced in scientific literature. Much of our knowledge about necroptosis comes from ligation of tumor necrosis factor-α to its receptor, TNF receptor 1. Receptor-interacting protein kinase 1, receptor-interacting protein kinase 3 and its substrate, the pseudokinase mixed lineage kinase domain-like protein, have been comprehensively st...
متن کاملMolecular insights into Parkinson's disease
Parkinson's disease is a neurodegenerative movement disorder characterized by loss of midbrain dopaminergic neurons leading to motor abnormalities and autonomic dysfunctions. Despite intensive research, the etiology of Parkinson's disease remains poorly understood leaving us with no effective therapeutic options. However, the recent identification of genes linked to heritable forms of Parkinson...
متن کاملMolecular insights into desmoid tumors
Desmoid tumors are rare, soft tissue tumors with no known capacity for metastasis. Although considered a benign lesion, desmoids can be locally aggressive and cause significant morbidity due to mass effect on adjacent structures and organs. Sites of involvement generally are the extremities, trunk, abdominal wall, and the intraabdominal region. Risk factors include induced situations such as hi...
متن کاملMolecular insights into eukaryotic chemotaxis.
Many cells display directed migration toward specific compounds. The best-studied eukaryotic models of chemotaxis are polymorphonuclear leukocytes, which respond to formylated peptides and Dictyostelium amoebas, which respond to extracellular cAMP. In both cell types, chemoattractants bind to surface receptors that contain seven transmembrane domains and interact with G proteins. Some cells, su...
متن کاملMolecular Insights into Evolution of Phenotypes
Success and e ciency of Darwinian evolution is based on the dichotomy of genotype and phenotype: The former is the object under variation whereas the latter constitutes the target of selection. Genotype-phenotype relations are highly complex and hence variation and selection appear uncorrelated. Population genetics visualizes evolutionary dynamics as a process among genotypes. Phenotypes are re...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2016
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm.2016.17