Molecular Mechanisms of Ion Selectivity in Potassium Channels
نویسندگان
چکیده
منابع مشابه
Molecular Simulations of Ion Permeation in Potassium Channels
specific steps in voltage-activation path of an ion channel are altered by a potent allosteric inhibitor. The Kþ channel peptide inhibitor guangxitoxin-1E (GxTX) is partial inverse agonist of the voltage gated potassium channel subtype Kv2.1 from rat. At saturating concentrations of GxTX, Kv2.1 requires higher voltages to activate. The GxTX modulated conductance requires more voltage to activat...
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Potassium channels play crucial roles in physiology, and one of their more important roles is to repolarize the membrane after an action potential in excitable cells (Hille, 2001). During an action potential, Na + chan nels open first and depolarize the cell membrane, which is followed closely by their inactivation and sub sequent opening of K + channels that repolarize the cell membrane by a...
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The conductance and selectivity of the Ca-activated K channel in cultured rat muscle was studied. Shifts in the reversal potential of single channel currents when various cations were substituted for Ki+ were used with the Goldman-Hodgkin-Katz equation to calculate relative permeabilities. The selectivity was Tl+ greater than K+ greater than Rb+ greater than NH4+, with permeability ratios of 1....
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Potassium (K(+)) channels are tetrameric membrane-spanning proteins that provide a selective pore for the conductance of K(+) across the cell membranes. These channels are most remarkable in their ability to discriminate K(+) from Na(+) by more than a thousandfold and conduct at a throughput rate near diffusion limit. The recent progress in the structural characterization of K(+) channel provid...
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was permeable to molecules as large as the 630 Da YO-Pasadena, California 91125 PRO-1 dye. This experiment demonstrated, for the first time, real time changes in ion selectivity for a molecularly defined, single ion channel species (but see Petrou et Membrane ion channels contain integral pores that pre-al., 1997). cisely select their permeant ions. This selectivity an-P2X Structure-Function Ba...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2020
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2019.11.2087